Adenocarcinoma treatment in Israel

Adenocarcinoma is a malignant tumor that develops from glandular cells of the affected organ. This is the most common type of cancer, as glandular cells line the inner surface of many organs (stomach, intestines, lungs, uterus, prostate, mammary glands, and others).

Depending on the structure and degree of maturation of malignant cells, adenocarcinoma can be:

• Well-differentiated – has the most favorable prognosis, rarely develops metastases, and responds well to treatment if diagnosed in time.
• Moderately differentiated – cells are less similar to healthy ones, the tumor often metastasizes, but with early diagnosis and modern comprehensive treatment, the prognosis is favorable.
• Poorly differentiated – the most aggressive type of adenocarcinoma, rapidly metastasizes, invades healthy tissues, and has an unfavorable prognosis.

If you have been diagnosed with adenocarcinoma, only oncologists from specialized clinics with extensive experience in treating this group of patients should manage your treatment. One such medical institution is the adult oncology department at Tel Aviv Medical Clinic.

We Offer Our Patients:

✔ High-quality, modern, comprehensive, and fast diagnostics. All necessary examinations can be completed at TAMC within 3–4 business days.

✔ A multidisciplinary approach to each individual case of adenocarcinoma. Depending on the tumor type and location, a whole team of professionals—including oncologists, surgeons, radiation therapists, chemotherapists, and other specialists—collaborates to provide care.

✔ Personalized treatment plans and unique therapy protocols. TAMC specialists often refine, enhance, and modify standard treatment protocols based on the specific characteristics of the patient and their tumor. This approach allows for success even in the most complex cases.

✔ Participation in clinical trials of new drugs and treatment methods free of charge. The only requirement is to meet the study criteria and have the willingness to participate. In many cases, this is the only chance for a patient to overcome a severe illness.

✔ Innovative genetic diagnostics, allowing for the development of a more effective treatment plan and selection of personalized immunobiological drugs.

✔ Cutting-edge treatment methods and medications, actively implemented in medical practice.

✔ Treatment by Israel’s leading specialists with a global reputation.

✔ Innovative immunobiological drugs – Trastuzumab, Lynparza (Olaparib), Dostarlimab.

✔ Minimally invasive surgical procedures.

✔ Safe and effective radiation therapy using state-of-the-art, next-generation equipment.

Causes of Adenocarcinoma

Unfortunately, there is no single cause for adenocarcinoma development. Depending on the tumor’s location, the main risk factors include:

• Salivary gland adenocarcinoma – smoking.
• Esophageal adenocarcinoma – mucosal burns, acid damage from reflux esophagitis.
• Stomach adenocarcinoma – chronic gastritis, peptic ulcer disease, Helicobacter pylori infection.
• Prostate adenocarcinoma – hormonal imbalances.
• Uterine adenocarcinoma – hormonal imbalances.
• Breast adenocarcinoma – genetic predisposition, hormonal imbalances.
• Liver adenocarcinoma – viral hepatitis, liver cirrhosis.

Symptoms of Adenocarcinoma

Unfortunately, there are no specific early signs of the disease. All adenocarcinoma symptoms can be divided into general and local symptoms. Local symptoms depend on the tumor’s location, size, and stage of malignancy.

General Symptoms:

• Weight loss.
• Loss of appetite.
• Persistent fever.
• General weakness and fatigue.
• Chronic anemia.

Local Symptoms:

• Stomach – epigastric pain, nausea, vomiting, feeling of fullness, bleeding.
• Lungs – cough, shortness of breath, hemoptysis, chest pain.
• Breasts – changes in breast shape, color, and size, nipple discharge, skin changes, pain.
• Prostate – urination issues, perineal pain, blood in urine, erectile dysfunction.
• Ovaries – abdominal pain, bloating, abdominal enlargement, menstrual irregularities.
• Intestines – diarrhea or constipation, abnormal stool contents, abdominal pain.
• Uterus – lower abdominal pain, enlarged abdomen, menstrual cycle irregularities, bleeding.

Unfortunately, most adenocarcinomas are diagnosed at late stages because patients ignore their symptoms for too long. If you notice persistent health changes that do not improve within a few days, consult a doctor immediately for proper evaluation and further tests.

Modern Diagnostic Methods

Comprehensive TAMC diagnostics take 3–4 business days. During this time, the patient consults with a leading oncologist, undergoes examination, laboratory tests, biopsy, imaging studies (CT, MRI, PET-CT, ultrasound), and genetic diagnostics. Afterward, a personalized treatment plan is provided during a follow-up consultation.

Mandatory tests include clinical and biochemical blood tests, as well as tumor markers.

Biopsy

A biopsy is a mandatory procedure for suspected adenocarcinoma. It can be performed before surgery or involve tissue samples obtained during a surgical procedure. If the patient has already undergone a biopsy at another medical facility, it is essential to bring tissue samples (glass slides, paraffin blocks) for reevaluation, which is cheaper than repeating the biopsy.

For tumor imaging, advanced methods are used based on tumor location: MRI, CT, MSCT, ultrasound, PET-CT, PET-MRI.

Genetic Diagnostics

All biopsy samples undergo genetic profiling in top U.S. laboratories to verify the diagnosis and determine the genetic makeup of cancer cells.

All TAMC patients have access to modern genetic diagnostics, an essential part of contemporary cancer diagnostics. Many cancers develop due to specific genetic mutations. Molecular-genetic testing allows us to detect these “genetic defects” and select the most effective treatment based on genetic variations.

Examples of genetic testing for lung adenocarcinoma:

• Allele-specific PCR sequencing for EGFR, HER2, METex14 mutations.
• Next-generation sequencing (NGS) for EGFR, HER2, METex14 mutations, ALK translocations.
• Fluorescent in situ hybridization (FISH) to detect gene translocations and abnormalities, including ALK translocations.
• Polymerase chain reaction (PCR) for EGFR mutations.
• Immunohistochemistry (IHC) for ALK translocation detection.

Prognosis for Adenocarcinoma

The prognosis primarily depends on tumor type, differentiation degree, malignancy, diagnosis stage, tumor location, overall patient health, and quality of medical care received.

• Early-stage diagnosis with modern treatment approaches offers a favorable prognosis.
• Late-stage detection with metastases requires aggressive treatment, including experimental therapies.

Modern Adenocarcinoma Treatment

At TAMC, we combine multiple treatment approaches to maximize success. Depending on the tumor location and stage, treatment includes:

✔ Surgery – often performed using minimally invasive techniques (laparoscopy, hysteroscopy, bronchoscopy, thoracoscopy, gastroscopy).
✔ Chemotherapy – administered before surgery (to shrink the tumor) or after surgery (to eliminate remaining cancer cells).
✔ Radiation therapy – using advanced linear accelerators for precise tumor targeting while sparing healthy tissues (SBRT, IMRT techniques).
✔ Brachytherapy – internal radiation therapy, used for prostate adenocarcinoma and others.
✔ Targeted and immunotherapy – modern drugs like Trastuzumab, Lynparza (Olaparib), Dostarlimab.
✔ Participation in clinical trials – offering patients free access to innovative treatments.

Why Choose TAMC?

✅ One of Israel’s largest oncology centers with state-of-the-art equipment.
✅ Personalized treatment protocols for complex cases.
✅ World-renowned oncologists.
✅ Access to cutting-edge clinical trials.

☎ Contact us today to schedule a consultation!