A multi-center phase I study of clofarabine, etoposide and cyclophosphamide in combination in pediatric patients with refractory or relapsed acute leukemia
Treatment of cancer in the Israeli clinic Tel Aviv Medical Clinic carried out using cutting-edge therapy methods, which can increase the efficiency by more than 90% and reduce the risk of re-occurrence of the disease. Our medical staff practices complex therapy, so our patients can consult with related specialists. Thanks to the latest equipment and the use of unique techniques, detecting a cancer tumor at an early stage with 100% accuracy is possible. And 90% of our patients were successfully cured with the help of the latest drugs, such as cyclophosphamide.
Cyclophosphamide
Cyclophosphamide is an antitumor drug that has a cytostatic effect of the alkylating type. It has a pronounced immunosuppressive effect with inhibition of the activity of B- and not T-subpopulations of lymphocytes. This drug prescribed for the treatment of the following pathologies:
- various types of leukemia;
- forms of myeloma;
- ovarian cancer;
- sarcomas;
- genetic syndrome;
- rheumatoid arthritis;
- preparation for bone marrow transplantation and others.
Before introducing the medication, the patient must undergo a diagnostic examination, which includes a blood and urine test, an ultrasound of the internal organs, and a biopsy of the affected tissues. The dosage of this substance is 2-8 mg/kg, the doctor administers the drug intravenously once a day. The course of chemotherapy is three weeks. Then a break is made.
What are the complications and contraindications of the drug?
Cyclophosphamide not administered to a patient with the following symptoms:
- hypersensitivity to components;
- pregnancy;
- lactation period;
- severe renal impairment;
- bone marrow hypoplasia;
- leukopenia;
- anemia;
- severe cachexia;
- terminal stages of cancer pathologies.
After a course of chemotherapy with cyclophosphamide, the following negative consequences were observed in patients:
- vomiting or diarrhea;
- the appearance of itching;
- headache;
- abdominal pain;
- shortness of breath;
- impaired liver and kidney function;
- increased fatigue;
- painful or difficult urination.
Doctors at Tel Aviv Medical Clinic keep up to date and try to use only the most advanced treatment methods that are effective and safe for the patient. Our medical staff has international certificates, which confirm the quality of services.